Scientists from the Medical Research Council (MRC) Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh have discovered an enzyme that corrects the most common mistake in mammalian DNA. The mistake is the inclusion of indi…
Melanoma is the most deadly form of skin cancer, estimated by the National Cancer Institute to afflict more than 70,000 people in the United States annually and the incidence rate continues to rise. In a study published online in Genome Research, resea…
Access to samples is paramount to scientific research. Biological samples such as DNA, RNA, proteins, cells and tissues are collected from donors, processed and stored centrally for later use in experiments conducted by academia and industry alike. Thi…
Geneticist Michael Snyder, PhD, has almost no privacy. For more than two years, he and his lab members at the Stanford University School of Medicine pored over his body’s most intimate secrets: the sequence of his DNA, the RNA and proteins produced by …
By engineering cells to express a modified RNA called “Spinach,” researchers have imaged small-molecule metabolites in living cells and observed how their levels change over time. Metabolites are the products of individual cell metabolism. The ability …
A new study, published in the March 9 issue of Science , reveals that by engineering cells to express a modified RNA called “Spinach”, researchers from the Weill Cornell Medical College have advanced in reproducing small-molecule metabolites, i.e. inte…
Although researchers have been investigating cancer treatments based on RNA interference – a method that can switch off malfunctioning genes with short snippets of RNA – for the past 10 years, they still need to find a technique to transport RNA effici…
For the past decade, scientists have been pursuing cancer treatments based on RNA interference – a phenomenon that offers a way to shut off malfunctioning genes with short snippets of RNA. However, one huge challenge remains: finding a way to efficient…
Small RNA-based nucleic acid drugs represent a promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes, and researchers have discovered new mechanisms by which RNA drugs can control gene activity. A comprehe…
Cells rely on purines, which are types of molecules that make up half of the DNA and RNA building blocks, and are a key component of the chemicals that store a cell’s energy in order to perform many vital functions. The purine supply is strictly contro…
